Study on the Changes of Bone Marrow CD235a+ Nucleated Red Blood Cell Apoptosis and Signal Pathways in Patients with Chronic Altitude Sickness

This study explored the changes in bone marrow CD235a+ nucleated red blood cell apoptosis and signal pathways patients with chronic mountain sickness. We collected data from 21 sickness 20 non-chronic patients. Bone mononuclear cells, flow cytometry is used to detect apoptotic index of cells determine mitochondrial membrane potential; reverse transcription quantitative polymerase chain reaction was related gene messenger RNA expression level, western blot erythrocyte apoptosis-related protein level compared indicators between two groups. Here, we found that negatively correlated accumulation cells. At same time, positively hemoglobin. The decrease levels pathway indicates change potential reduction release nuclear will also cause apoptosis.